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Trials on stroke and traumatic brain injuries with competitive glutamate or glycine antagonists (i.e., selfotel, aptiganel, eliprodil, licostinel, and gavestinel) have failed ( ALCAR Acetyl-L-carnitine (-trimethyl--acetylbutyrrobetaine) is an acetyl ester of carnitine, an endogenous molecule with pleiotropic biological and pharmacological activities on central and peripheral nervous systems (Tolu et al., 2002